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KMID : 0378019750180020168
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New Medical Journal
1975 Volume.18 No. 2 p.168 ~ p.172
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Changes of the Lactate Dehydrogenase (LDH) Isoenzyme Patterns in the Developing Rabbit´s Retina and Cerebrum
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Abstract
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LDH isoenzyme patterns in the developing rabbit´s retina and cerebrum have been studied by cellulose acetate electrophoresis. The isoenzyme distribution differed between the two organs, the retina and the cerebrum.
A remarkable predominance of M-type in the LDH isoenzyme was observed in the retina after 8- and 12-day-neonatal rabbits. In the 17-day-rabbit, there was a substantial change in the isoenzyme distribution, thus LDH5 still predominated in the enzyme activities though showed a relative weakened figures. The LDH isoenzyme distribution in the retina from 7-week-rabbit showed intermediate patterns. The total activities in the rabbit´s retina were slightly increased as development progresses but there were pronounced changes in the LDH isoenzyme patterns.
In the zymograms obtained from the developing rabbits´s cerebrum, the most remarkable activities were confirmed as LDH2, LDH3, and LDH4 patterns and such activity patterns were lasted thoughout the present experiments. A gradual decrease of LDH5 was observed in the 17-day-rabbits. On the other hand, H-type LDH subunit was siginificantly increased in the cerebrum.
From the view point of the developmental process, the differentiation of the isoenzyme patterns is more progressed in the rabbit´s cerebrum than retina. Also the period the attain maturated patterns is shorter in the rabbit´s cerebrum than retina.
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